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Contraindicated (1)pentobarbital will lower the level or outcome of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the extent or outcome of doxorubicin liposomal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Elderly or debilitated people may well respond to bar